Following Autism Supplement Routine Again

January turned out to be a difficult month. I wouldn’t say it was bad, or hard – just difficult. G started wearing the foot orthotics in the first week of January. He eased into it but then started wearing them all day while at therapy. I really didn’t think they bothered him. He would even point at the orthotics when at home and want to put them on. All the signs of him liking them were there. But it really seems like they were bothering him and blocking his sensory input. He just needs to get up on his toes. It’s an outlet for him. He couldn’t and he was getting angry. He was hitting and trying to scratch us. He was poking his therapists, trying to hit them, trying to hit other peers, and getting so upset about many little things. He could barely even eat dinner some nights. None of us knew what was wrong. We were starting to get really stressed and really down. I decided to have him just stop wearing the orthotics as a first step. In the first day of him not wearing them to therapy, he became happier. Within the next few days, he was almost back to normal. And now almost two weeks later, he is so much better. He’s so much better that the past weeks are a blur now. The fact we had to have a behavior meeting at therapy is a blur. I am so relieved.

This whole thing made me rethink his supplements. He was not taking anything extra in his food, pretty much, for almost a year. I took a break from dissecting all of that information and from dealing with all of us hiding things in his food. But now I am back on track and have the new regimen. It seems to be making him even more calm, focused and happy. Will keep building on this and see where it takes us.

Morning: (1/2 tsp) Leucovorin in yogurt

Afternoon: (1/2 tsp) Leucovorin, (1) pau d’arco, (2) quercetin and bromelain in puree

Water with fractionally distilled aloe vera and cromolyn sodium before nap

Dinner: (1) zinc picolinate, (1) calcium in yogurt

Why leucovorin?

Biochemically in the body, folic acid supports cellular perception and response, methylation processes and many enzymatic reactions. It is also linked to maintaining healthy homocysteine levels, which supports cardiovascular health.

To be active in the body, folic acid has to be reduced twice by folate reductase enzymes, then converted to tetrahydrofolate, after which a methyl group is added to the tetrahydrofolate. In some individuals, the use of natural folinic acid may be more beneficial than folic acid, because folinic acid already has attached four hydrogen and one methyl group, thereby shortcutting the complicated biochemical process.

Why pau d’arco?

Pau D’Arco is a tropical tree that has been used by natives in the Amazon as a folk remedy for hundreds of years. Pau D’Arco is an immune stimulant and helps keep the gastro-intestinal system healthy, making it less hospitable to yeast, parasitic, bacterial, fungal and viral infections. Studies have shown Pau D’Arco to be anti-inflammatory and anti-oxidant, as well.

Why quercetin and bromelain?

Quercetin helps ensure appropriate immune response, inhibits formation of free radicals and promotes circulatory health in part by supporting the integrity of small blood vessels.

Bromelain complements quercetin for appropriate immune response and cardiovascular health, while also promoting joint comfort. (Bromelain may enhance the transport of the bioflavonoids (like quercetin) across the intestinal membrane.)

Quercetin Bromelain supplies the flavonoid quercetin extracted from seed pods of the Dimorphandra mollis plant. Flavonoids are potent protective nutrients found in many plants and foods. Bromelain is an enzyme derived from pineapple.

In autism with possibility of inflammation or histamine problems, Quercetin functions on an antioxidant level to reduce damage and irritation caused by free radicals while suppressing histamine response – the body’s reaction to allergens. Bromelain functions on an enzymatic and protein level by limiting the action of metabolites and neutrophils on inflammation.

Why zinc picolinate?

From this article: International studies have found that normally there are high levels of zinc in the brain, and brain cells are regulated by zinc, but that zinc deficiency is prevalent in autistic children.

“Research using animal models has shown that when a mother is given a low zinc diet, the offspring will be more likely to display autistic associated behaviours,” she says.

“Our work is showing that even the cells that carry genetic changes associated with autism can respond to zinc.

“Our research has focussed on the protein Shank3, which is localized at synapses in the brain and is associated with neuro-developmental disorders such as autism and schizophrenia,” she says.

“Human patients with genetic changes in Shank3 show profound communication and behavioural deficits. In this study, we show that Shank3 is a key component of a zinc-sensitive signalling system that regulates how brain cells communicate.”

Why cromolyn sodium?

Cromolyn sodium works by preventing the release of substances in the body that cause inflammation. Cromolyn sodium originally derived from a healing herb called ammi visnaga. Among its other uses, ammi visnaga traditionally controlled kidney stone pain. Its ability to open the airways intrigued early researchers. They eventually identified the plant’s active ingredient: cromolyn sodium. Cromolyn sodium is known to prevent mast cells from triggering the immune response.

Why fractionally distilled aloe vera?

Aloe vera contains nearly 200 biologically active components, including polysaccharides, vitamins, enzymes and minerals. It helps balance the stomach’s pH levels and promotes healthy bacteria growth.

Why calcium?

Just because we need to get that back on track as well as Vitamin D, soon after.

As for the orthotics, he is already on a program at therapy where he is told to do “flat feet” so we will continue with the verbal prompts and see how much better he gets with it. But really for right now it’s not a big concern anymore. If he needs to do that sometimes, then he just needs to until we can find another way for him to get sensory input.

March goals? Test G to see if he has folate receptor autoantibodies. If he tests positive for those, it means that he definitely is benefiting from taking leucovorin (folinic acid) and should continue. Some studies show that as much as 60%+ of people with autism have these autoantibodies.

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