My Olive Oil File

Mediterranean countries account for approximately 70% of all global olive oil (OO) production, which is mainly undertaken by Spain, Turkey, Greece, Italy, Morocco, and Tunisia [1]. Not only have the beneficial effects of OO (Olea europaea L.) been evaluated in the context of the so-called Mediterranean diet [2] but also due to its largely recognized bioactivity [3]. Thus, the regular consumption of OO is currently associated with beneficial effects on health due to its specifically nutritional components. 

Concerning minor constituents, triterpenic and phenolic compounds, tocopherols and sterols contained in EVOO have been involved in a variety of biological activities, including the activation of different signaling pathways related to redox state, homeostasis, inflammation [10,11] and epigenetics modifications of the chromatin.

Moreover, neurodegenerative diseases [18] and cancer [19] presented with lower incidence in the context of the Mediterranean diet, which was in part attributed to the regular consumption of EVOO. 

5. Conclusions 

In conclusion, our study demonstrates the presence of increased oxidative stress and inflammation in the choroid and retina in a mouse model of L-NAME-induced hypertension. More importantly, we show—for the first time—that ACE (wild olive) oil showed a greater ability to counteract the pathogenic mechanisms of hypertensive eye diseases when compared with a reference EVOO of a similar geographic origin, including systemic anti-hypertensive effects and a significant improvement in hypertension-related oxidative retinal damage. These better outcomes in favor of ACE oil might be attributable to a higher content of sterols, tocopherols, triterpenes and secoiridoids in comparison with EVOO. We claim that the rational use of ACE oil-enriched diets can offer a novel retinoprotective strategy to neutralize AH-related retinal oxidative damage and associated pathologies, including AMD, hypertensive retinopathy, glaucoma and other retinopathies, as well as choroidal vascular diseases.